Adipokines in inflammation and metabolic disease nature. Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. This paper describes the role of adipose tissue and the biological effects of many. Straub, in the origin of chronic inflammatory systemic diseases and their sequelae, 2015. It is closely related to metabolic disturbances in the adipose tissue that primarily functions as a fat reservoir. Furthermore, data demonstrating that increased circulating saa is a predictor of cardiovascular disease suggest that the secretion of acute phase reactants by adipose tissue is related to disease risk and therefore may have a negative impact on overall health 191, 192. This determines a chronic active inflammatory condition, associated with the development of the obesityrelated inflammatory diseases. This figure highlights 3 novel functions for adipokines that were recently described in atvb. The book targets endocrinologists, residents and fellows, internists, nutritionists and general practitioners who are exposed. The role of adipose tissue and adipokines in obesity. Long before the concept of adipose tissue as an immune organ began to capture the interest of scientists in the early 1990s, mesenteric fat had been shown to be an important indicator of regional disease activity in crohns disease cd patients. In contrast, excess adipose tissue expansion promotes dysfunction right, leading to the expression of proinflammatory adipokines that promote cardiovascular disease. Dynamics of human adipose lipid turnover in health and.
Over the past two decades following the discovery of leptin which directed much needed attention to the study of adipose tissue, it has been acknowledged that several adipokines regulate important biological processes in target organs including the brain, liver, skeletal muscle, vasculature, heart, immune system and pancreatic. Little is known, however, about adipose lipid turnover in humans in health and pathology. Since altered body composition, decrease of skeletal muscle mass, and development of pathologically changed mesenteric white adipose tissue are wellknown features of ibd and especially of crohns disease, we discuss the possible crosstalk between adipokines and myokines released from skeletal muscle during exercise with moderate or forced. These changes in adipose tissue function and distribution influence the secretion of adipose tissue derived hormones, or adipokines, that promote a chronic state of lowgrade systemic inflammation.
Adipose tissue, inflammation, and cardiovascular disease. Although great strides have been made in characterizing these hormones in health, research also. Within adipose tissue representative histologic slide of human omental adipose tissue, adipokines contribute to the regulation of adipogenesis, immune cell migration, adipocyte metabolism, triglyceride storage, and others. Jan 21, 2011 adipose tissue functions as a key endocrine organ by releasing multiple bioactive substances, known as adipose derived secreted factors or adipokines, that have proinflammatory or anti. Functions of adipose tissue and adipokines in health and disease. Adipose tissue and adipokines in health and disease presents a comprehensive survey of adipose tissue, its physiological functions, and its role in disease. Request pdf adipose tissue and adipokines in health and disease among different mechanisms that could lead to interindividual differences in obesity susceptibility, epigenetics has emerged, in. From a simple dormant site of energy storage, adipose tissue is now recognized as an integral hub of various hormones known as adipokines. Obesity significantly increases the risk for metabolic diseases type 2 diabetes mellitus t2dm, fatty liver disease, and dyslipidemia, cardiovascular disorders hypertension, coronary heart disease, and stroke, diseases of the central nervous system dementia, obstructive sleep apnea, and different types of cancer. The classical adipokines leptin, adiponectin, and resistin are expressed only by adipocytes, but other adipokines have been shown to be released by resident and infiltrating macrophages, as well as by components of the vascular stroma.
Fat accumulation in both adipose tissue and other organs contributes to a systemic inflammation leading to the development of metabolic disorders such as type 2 diabetes, hypertension, and. From leptin to other adipokines in health and disease. Dysregulated production or secretion of these adipokines owing to adipose tissue dysfunction can contribute to the pathogenesis of obesitylinked complications. Although additional, undiscovered adipokines may complete the final pieces of the puzzle, our current jigsaw reveals a sophisticated picture which intertwines disease and adipokines. White adipose tissue wat and brown adipose tissue bat are the predominant types in mammals. Soap web service annotations api oai service bulk downloads developers forum. Adipose tissue, adipokines, and inflammation sciencedirect. Obesity is an energyrich condition associated with overnutrition, which impairs systemic metabolic homeostasis and elicits stress.
Giamila fantuzzi and theodore mazzone, is a very welcome addition to the nutrition and health series and fully exemplifies the. Functions of adipose tissue and ad ipokines in health and disease 19 influences the proliferation, differentiation, acti vation and cytotoxicity of natural killer nk. Second edition adipose tissue and type 2 diabetes mellitus chapter may 2014 with 490 reads. Defined as an excess of adipose tissue, obesity remains one of the greatest healthcare epidemics of the 21st century. Immunologic and endocrine functions of adipose tissue. In biology, adipose tissue, body fat, or simply fat is a loose connective tissue composed mostly of adipocytes. For this reason, adipose tissue is considered as the primary site for initiation and aggravation of obesity and t2dm. Here, the authors discuss the immunologic and endocrine functions of adipose tissue that contribute to kidney disease and the converse effects of kidney dysfunction on adipose tissue.
A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Adipose tissue and adipokines in health and disease, edited by drs. Then you can start reading kindle books on your smartphone, tablet, or computer. Adipose tissue and adipokinesenergy regulation from the. Adipose tissue and inflammatory bowel disease pathogenesis. The stromal layer consists of adipose derived stem cells adscs or preadipocytes, fibroblasts, blood vessels, and nerve cells.
Adipose tissue and adipokines in health and disease request pdf. Adipose tissue and adipokines in health and disease, second edition contains updated chapters from the previous volume but as the field has evolved, some areas covered in the first edition have been refocused to address the new knowledge. Ultimately, obesity accelerates aging by enhancing inflammation and increasing the risk of ageassociated diseases. The adipose tissue pool in mammals is composed of at least two functionally distinct types of fat. Two types of adipose tissue are present in mammals.
Two decades of research have now shown that ats act as an endocrine organ, secreting soluble factors termed adipocytokines or adipokines. Cardiovascular disease cvd, diabetes mellitus and insulin resistance, and other obesityrelated disorders remain a heavy disease burden in the united states and throughout the world. Within adipose tissue representative histologic slide of human omental adipose tissue, adipokines contribute to the regulation of adipogenesis, immune cell migration, adipocyte metabolism, triglyceride storage, and. In addition, to the wellestablished role of metabolites originating from adipose tissue e. Wat is an endocrine tissue that secretes hundreds of compounds, which are called adipokines when wat is thought to be the major source. Adipokines are peptides that signal the functional status of adipose tissue to targets in the brain, liver, pancreas, immune system, vasculature. Jul 01, 2006 studies on white adipose tissue have led to the recognition that it is an important endocrine organ, communicating with the brain and peripheral tissues through the secretion of leptin and other adipokines. As a key endocrine organ, the adipose tissue communicates with other organs, such as. From a simple dormant site of energy storage, adipose tissue is now. In parallel, obesity is characterized by either decreased or dysregulated secretion of antiinflammatory adipokines e. Adipokines oversecreted by omental adipose tissue in human. Adipose is an important endocrine and immunologic organ, releasing various adipokines and cytokines that regulate the adipocyte microenvironment and. Adipokines adipose tissue cytokines are polypeptide factors secreted by adipose tissue in a highly regulated manner.
Different cell types of adipose tissue adipocytes, immune cells, fibroblasts, endothelial cells and others release fatty acids, other lipids and metabolites and adipokines. Role of obesity, mesenteric adipose tissue, and adipokines in. Perivascular adipose tissue and coronary vascular disease. Accumulation of excess adipose tissue, particularly in visceral adipose tissue depots, enhances the secretion of proinflammatory adipokines and chemokines into the systemic circulation. Adipose tissue as a source of inflammatory cytokines in. Hypertrophy over hyperplasia, adipose tissue macrophagesm1 phenotype. Per definition, adipokines are produced by adipocytes, which are closely related to fibroblasts.
Role of obesity, mesenteric adipose tissue, and adipokines. Adipose tissue as a source of inflammatory cytokines in health and disease. Thus, adipose tissue secretes a variety of bioactive peptides that play important roles in insulin action, energy. A dysregulation of these processes leading to increases in serum triglyceride and free fatty acid ffa levels combined with the deposition of. Dysfunctional adipose tissue is characterized by enlarged adipocytes, vascular rarefaction, increased inflammatory cell infiltrate, and the appearance of crownlike structures. Request pdf adipose tissue and adipokines in health and disease adipokines are peptides mostly secreted by adipocytes and capable of acting at both the local autocrineparacrine and systemic. Pdf adipose tissue, adipokines, and inflammation researchgate. Obesity is an established cardiovascular risk factor, conventionally defined as a body mass index 30 kgm 2, that predisposes to metabolic abnormalities and cardiovascular disease cvd. Adipose tissue is an essential organ and is the primary site for energy storage as triacylglycerols tgs. Enter your mobile number or email address below and well send you a link to download the free kindle app.
Adipokines, such as leptin, il6, tnf, visfatin, adiponectin, resistin, omentin, and others are a group of cytokines secreted by the adipose tissue. In addition to adipocytes, adipose tissue contains the stromal vascular fraction svf of cells including preadipocytes, fibroblasts, vascular endothelial cells and a variety of immune cells such as adipose tissue macrophages. The endocrine function of adipose tissues in health and. The role of adipose tissue and adipokines in obesityrelated. Animal fat stored in the tissue of the body 2007, giamila fantuzzi. Adipose tissue functions as a key endocrine organ by releasing multiple bioactive substances, known as adiposederived secreted factors or adipokines, that have proinflammatory or. This volume contains a collection of information spanning the entire range of adipose tissue studies, from basic. Differential adipokine secretion by each adipose tissue depot may selectively. Summary of recent advances in roles for adipokines in cardiovascular disease. Adipose tissue dysfunction contributes to obesity related. Adipose tissue in health and disease wiley online books. As consequence, increased circulating levels of proinflammatory cytokines, hormonelike molecules, and other inflammatory markers are. It also activates an inflammatory process in metabolically active sites, such as white adipose tissue, liver, and immune cells. Adipose tissue, comprising mainly adipocytes and immune cells, exerts endocrine effects on distant tissues through the secretion of adipokines, such as adiponectin and leptin.
Adipose tissue and adipokines in health and disease. Adipose tissue itself comprises multiple cell types, including adipocytes. This volume spans the entire range of adipose tissue studies, from basic anatomical and physiological research to epidemiology and clinical studies. Adipose tissue mass is determined by the storage and removal of triglycerides in adipocytes 1. The protein factors are commonly referred to as adipokines. Adipose tissue and adipokines in health and disease nutrition and health fantuzzi, giamila, mazzone, theodore, goldberg, a. Adiponectin is one of the only adipocytesecreted protein with beneficial effects on health and disease due to its role in lipid metabolism and glucose homeostasis. Jcm free fulltext adipose tissuederived signatures. Adipose tissue and adipokines in health and disease pdf free. Importantly, with the development of at dysfunction, adipokine secretion is significantly altered toward a proinflammatory, atherogenic and diabetogenic pattern. This is especially true in the case of crohns disease.
Since then, leptin has represented the prototype for all subsequently identi. The aim of adipose tissue and adipokines in health and disease is to provide comprehensive information regarding adipose tissue, its physiological functions and its role in disease. Pdf functions of adipose tissue and adipokines in health. There is a rapidly expanding list of protein factors released by white adipose tissue, including the key hormone, adiponectin. This paper describes the role of adipose tissue and the biological effects of many adipokines in these diseases.
Buy adipose tissue and adipokines in health and disease nutrition and health. The recent results indicate a special role of visceral adipose. Wat is a complex tissue consisting of multiple cell types with multiple cellular phenotypes depending on cell composition and location. Adipokines are peptides that signal the functional status of adipose tissue to targets in. Obesityinduced changes in adipose tissue microenvironment. Jcm free fulltext adipose tissuederived signatures for. This volume contains a collection of information spanning the entire range of adipose tissue studies, from basic anatomical and physiological research to. Wat represents the vast majority of adipose tissue in the organism and is the site of energy storage, whereas the main role of brown adipose tissue is nonshivering thermogenesis, particularly in small mammals and human neonates. The growing prevalence of obesity and its related metabolic diseases, mainly type 2 diabetes t2d, has increased the interest in adipose tissue at and its role as a principal metabolic orchestrator. Through the identification of leptin, our perceived understanding of adipose tissue was changed instantaneously. Dynamics of adipose tissue turnover in human metabolic. Download citation adipokines in health and disease obesity increases the risk for metabolic, cardiovascular, chronic inflammatory, and several malignant diseases and, therefore, may contribute. Willis md, phd, in cellular and molecular pathobiology of cardiovascular disease, 2014. Obesity is becoming increasingly more common among patients with inflammatory bowel disease and plays a role in the development and course of the disease.
Pdf white adipose tissue is no longer considered an inert tissue mainly. Obesity is defined as a condition of abnormal or excessive fat accumulation in white adipose tissue that results from the exacerbated consumption of calories associated with low energy expenditure. Stimulated by the discovery of leptin and the notion that adipose tissue is an endocrine organ, more than six hundred adipokines have been described so far and search for. Sep 17, 2014 although additional, undiscovered adipokines may complete the final pieces of the puzzle, our current jigsaw reveals a sophisticated picture which intertwines disease and adipokines. This adipokine imbalance is thought to be a key event in promoting both systemic metabolic dysfunction and cardiovascular disease. One current mechanism integrating the two is that obesity results in hypertrophy of adipose tissue which in turn induces hypoxia. Emerging roles for adipose tissue in cardiovascular disease. The endocrine function of adipose tissue may provide insight as to underlying mechanisms linking adipose tissue to the major neurodegenerative and vascular disease of aging cognitive impairments and dementia. Coronary perivascular adipose tissue pvat is a visceral adipose tissue of mesothelial origin that normally surrounds the major coronary arteries on the surface of the heart. It represents the major source of fatty acids ffa in the postprandial fasting state for energy use and heat production. Adipose tissue and adipokines in health and disease giamila. Dahlman i, elsen m, tennagels n, korn m, brockmann b, sell h, eckel j.
Adipose tissue is a necessary survival characteristic of species that do not have constant access to food. The main functions of adipose tissue include the storage of. Obesity is one of the main risk factors for type 2 diabetes mellitus t2dm. Adipose tissue and adipokines in health and disease ebook by. When there is an excess of nutrients, watstores free fatty acids ffas in the. Adipose tissue and adipokines in health and disease, second edition is a useful resource for physicians interested in adipose tissue biology and basic scientists who want to know more about applied aspects of the field. Inflammatory bowel diseases ibds are a group of disorders which include ulcerative colitis and crohns disease. Adipokines are a family of hormones and cytokines with both pro and antiinflammatory effects that are secreted by adipose tissue.
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